PLASMA ENDOTHELIN-1 LEVELS IN PATIENTS WITH DIABETES-MELLITUS WITH OR WITHOUT VASCULAR COMPLICATION

被引：25

作者：

KANNO, K ^{[1
]}

HIRATA, Y ^{[1
]}

SHICHIRI, M ^{[1
]}

MARUMO, F ^{[1
]}

机构：

[1] TOKYO MED & DENT UNIV, DEPT INTERNAL MED 2, 1-5-45 YUSHIMA, BUNKYO KU, TOKYO 113, JAPAN

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 17卷

关键词：

ENDOTHELIN-1; DIABETES-MELLITUS; PLASMA GLUCOSE; ANGIOPATHY;

D O I：

10.1097/00005344-199100177-00136

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Plasma endothelin-1 (ET-1) concentrations were measured in 25 patients with non-insulin-dependent diabetes mellitus (11 with angiopathy and 14 without angiopathy) and 21 normal subjects using radioimmunoassay specific to ET-1. Basal plasma immunoreactive (ir) ET-1 levels in diabetic patients with and without angiopathy were 1.73 +/- 0.29 and 1.68 +/- 0.20 pg/ml, respectively. Although high glucose levels may stimulate ET-1 release from vascular endothelial cells in vitro, our data suggest that circulating ET-1 may not be elevated in most diabetic patients with or without angiopathy.

引用

页码：S475 / S476

页数：2

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