CARDIAC CHLORIDE CHANNELS

被引：60

作者：

ACKERMAN, MJ

CLAPHAM, DE

机构：

来源：

TRENDS IN CARDIOVASCULAR MEDICINE | 1993年 / 3卷 / 01期

关键词：

D O I：

10.1016/1050-1738(93)90024-Z

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cardiac chloride channels, once largely ignored, are the subject of renewed exploration. Consequently, their molecular identities and electrophysiologic properties are being defined and have revealed a distinct family of ionic channels capable of uniquely influencing the cardiac action potential Targeting these channel proteins may provide novel antiarrhythmic strategies.

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页码：23 / 28

页数：6

相关论文

共 42 条

[1] NUCLEOSIDE TRIPHOSPHATES ARE REQUIRED TO OPEN THE CFTR CHLORIDE CHANNEL [J].

ANDERSON, MP ;

BERGER, HA ;

RICH, DP ;

GREGORY, RJ ;

SMITH, AE ;

WELSH, MJ .

CELL, 1991, 67 (04) :775-784

[2] DEMONSTRATION THAT CFTR IS A CHLORIDE CHANNEL BY ALTERATION OF ITS ANION SELECTIVITY [J].

ANDERSON, MP ;

GREGORY, RJ ;

THOMPSON, S ;

SOUZA, DW ;

PAUL, S ;

MULLIGAN, RC ;

SMITH, AE ;

WELSH, MJ .

SCIENCE, 1991, 253 (5016) :202-205

[3] CHLORIDE CONDUCTANCE REGULATED BY CYCLIC AMP-DEPENDENT PROTEIN-KINASE IN CARDIAC MYOCYTES [J].

BAHINSKI, A ;

NAIRN, AC ;

GREENGARD, P ;

GADSBY, DC .

NATURE, 1989, 340 (6236) :718-721

[4]

BEAR CE, 1991, J BIOL CHEM, V266, P19142

[5] CHLORIDE IONS AND MEMBRANE POTENTIAL OF PURKINJE FIBRES [J].

CARMELIET, E .

JOURNAL OF PHYSIOLOGY-LONDON, 1961, 156 (02) :375-&

[6] CYSTIC-FIBROSIS - MOLECULAR-BIOLOGY AND THERAPEUTIC IMPLICATIONS [J].

COLLINS, FS .

SCIENCE, 1992, 256 (5058) :774-779

[7]

CURTIS MJ, 1989, J MOL CELL CARDIO S2, V21, P421

[8] CHLORIDE CONDUCTANCE EXPRESSED BY DELTA-F508 AND OTHER MUTANT CFTRS IN XENOPUS OOCYTES [J].

DRUMM, ML ;

WILKINSON, DJ ;

SMIT, LS ;

WORRELL, RT ;

STRONG, TV ;

FRIZZELL, RA ;

DAWSON, DC ;

COLLINS, FS .

SCIENCE, 1991, 254 (5039) :1797-1799

[9] ANION CHANNELS ACTIVATED BY ADRENALINE IN CARDIAC MYOCYTES [J].

EHARA, T ;

ISHIHARA, K .

NATURE, 1990, 347 (6290) :284-286

[10] Electrolytes in muscle [J].

Fenn, WO .

PHYSIOLOGICAL REVIEWS, 1936, 16 (03) :0450-0487

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