ENDOTHELIN-INDUCED CONSTRICTION OF GUINEA-PIG AIRWAYS - ROLE OF PLATELET-ACTIVATING FACTOR

被引：32

作者：

BATTISTINI, B ^{[1
]}

SIROIS, P ^{[1
]}

BRAQUET, P ^{[1
]}

FILEP, JG ^{[1
]}

机构：

[1] UNIV SHERBROOKE,FAC MED,DEPT PHARMACOL,SHERBROOKE J1H 5N4,QUEBEC,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1990年 / 186卷 / 2-3期

基金：

英国医学研究理事会;

关键词：

(Guinea-pig); BN; 52021; Bronchi (upper); Endothelin; PAF (platelet-activating factor; PAF-acether); Trachea;

D O I：

10.1016/0014-2999(90)90449-G

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Endothelin-1 (ET-1, 1-100 nM) evoked a concentration-dependent contraction of guinea pig trachea and upper bronchi in vitro. The response was significantly attenuated by BN 52021 (ginkgolide B, 10 μM), a specific receptor antagonist to platelet-activating factor. Precontraction of the tissues with endothelin (50 nM) desensitized tissues to platelet-activating factor (200 nM), while preincubation of the tissues with platelet-activating factor slightly inhibited the response to endothelin. These findings suggest that platelet-activating factor may mediate endothelin-induced airway contraction in the guinea pig. © 1990.

引用

页码：307 / 310

页数：4

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