TEL1, A GENE INVOLVED IN CONTROLLING TELOMERE LENGTH IN SACCHAROMYCES-CEREVISIAE, IS HOMOLOGOUS TO THE HUMAN ATAXIA-TELANGIECTASIA GENE

被引：350

作者：

GREENWELL, PW

KRONMAL, SL

PORTER, SE

GASSENHUBER, J

OBERMAIER, B

PETES, TD

机构：

[1] UNIV N CAROLINA, CURRICULUM GENET & CELL BIOL, CHAPEL HILL, NC 27599 USA

[2] UNIV CHICAGO, DEPT MOLEC GENET & CELL BIOL, CHICAGO, IL 60637 USA

[3] UNIV MUNICH, INST BIOCHEM, D-81375 MUNICH, GERMANY

来源：

CELL | 1995年 / 82卷 / 05期

关键词：

D O I：

10.1016/0092-8674(95)90479-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G(1-3)T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amio acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.

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页码：823 / 829

页数：7

相关论文

共 46 条

[1] DNA-REPAIR MUTANTS DEFINING G2 CHECKPOINT PATHWAYS IN SCHIZOSACCHAROMYCES-POMBE [J].

ALKHODAIRY, F ;

CARR, AM .

EMBO JOURNAL, 1992, 11 (04) :1343-1350

[2] A SIMPLE AND EFFICIENT METHOD FOR DIRECT GENE DELETION IN SACCHAROMYCES-CEREVISIAE [J].

BAUDIN, A ;

OZIERKALOGEROPOULOS, O ;

DENOUEL, A ;

LACROUTE, F ;

CULLIN, C .

NUCLEIC ACIDS RESEARCH, 1993, 21 (14) :3329-3330

[3]

BOEKE JD, 1987, METHOD ENZYMOL, V154, P164

[4] A MAMMALIAN PROTEIN TARGETED BY G1-ARRESTING RAPAMYCIN-RECEPTOR COMPLEX [J].

BROWN, EJ ;

ALBERS, MW ;

SHIN, TB ;

ICHIKAWA, K ;

KEITH, CT ;

LANE, WS ;

SCHREIBER, SL .

NATURE, 1994, 369 (6483) :756-758

[5] AN ELECTROPHORETIC KARYOTYPE FOR YEAST [J].

CARLE, GF ;

OLSON, MV .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (11) :3756-3760

[6] 2 DIFFERENTIALLY REGULATED MESSENGER-RNAS WITH DIFFERENT 5' ENDS ENCODE SECRETED AND INTRACELLULAR FORMS OF YEAST INVERTASE [J].

CARLSON, M ;

BOTSTEIN, D .

CELL, 1982, 28 (01) :145-154

[7] TELOMERE SHORTENING ASSOCIATED WITH CHROMOSOME INSTABILITY IS ARRESTED IN IMMORTAL CELLS WHICH EXPRESS TELOMERASE ACTIVITY [J].

COUNTER, CM ;

AVILION, AA ;

LEFEUVRE, CE ;

STEWART, NG ;

GREIDER, CW ;

HARLEY, CB ;

BACCHETTI, S .

EMBO JOURNAL, 1992, 11 (05) :1921-1929

[8] PHOSPHATIDYLINOSITOL 4-KINASE - GENE STRUCTURE AND REQUIREMENT FOR YEAST-CELL VIABILITY [J].

FLANAGAN, CA ;

SCHNIEDERS, EA ;

EMERICK, AW ;

KUNISAWA, R ;

ADMON, A ;

THORNER, J .

SCIENCE, 1993, 262 (5138) :1444-1448

[9]

FRIEDBERG EC, 1995, DNA REPAIR MUTAGENES, P662

[10] PIK1, AN ESSENTIAL PHOSPHATIDYLINOSITOL 4-KINASE ASSOCIATED WITH THE YEAST NUCLEUS [J].

GARCIABUSTOS, JF ;

MARINI, F ;

STEVENSON, I ;

FREI, C ;

HALL, MN .

EMBO JOURNAL, 1994, 13 (10) :2352-2361

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