CIRCULAR DNA RESULTING FROM RECOMBINATION BETWEEN V-(D)-J JOINING SIGNALS AND SWITCH REPETITIVE SEQUENCES IN MOUSE THYMOCYTES

被引：8

作者：

DAVIS, DD ^{[1
]}

YOSHIDA, K ^{[1
]}

KINGSBURY, L ^{[1
]}

SAKANO, H ^{[1
]}

机构：

[1] UNIV CALIF BERKELEY,DEPT MOLEC & CELL BIOL,DIV IMMUNOL,ROOM 441 LSA BLDG,BERKELEY,CA 94720

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1991年 / 173卷 / 03期

关键词：

D O I：

10.1084/jem.173.3.743

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

During the course of analyzing circular DNA in mouse thymocytes, novel recombinants were identified with immunoglobulin heavy chain joining gene and switch region probes. These circles represent excision products of recombination between the heptamer-nonamer motif for V-(D)-J joining and a repetitive sequence for class switching. The molecular mechanisms that generate "hybrid circles" are discussed.

引用

页码：743 / 746

页数：4

共 17 条

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