THE RELATED FLT4, FLT1, AND KDR RECEPTOR TYROSINE KINASES SHOW DISTINCT EXPRESSION PATTERNS IN HUMAN FETAL ENDOTHELIAL-CELLS

被引:214
作者
KAIPAINEN, A
KORHONEN, J
PAJUSOLA, K
APRELIKOVA, O
PERSICO, MG
TERMAN, BI
ALITALO, K
机构
[1] UNIV HELSINKI, DEPT PATHOL,MOLEC CANC BIOL LAB,POB 21, HAARTMANINK 3, SF-00014 HELSINKI, FINLAND
[2] INST INT GENET & BIOFIS, I-80125 NAPLES, ITALY
[3] AMER CYANAMID CO, LEDERLE LABS, DIV MED RES, PEARL RIVER, NY 10965 USA
关键词
D O I
10.1084/jem.178.6.2077
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The growth factor receptors expressed on endothelial cells are of special interest because of their potential to program endothelial cell growth and differentiation during development and neovascularization in various pathological states, such as wound healing and angiogenesis associated with tumorigenesis. Vascular endothelial growth factor ([VEGF] also known as vascular permeability factor) is a potent mitogen and permeability factor, which has been suggested to play a role in embryonic and tumor angiogenesis. The newly cloned FLT4 receptor tyrosine kinase gene encodes a protein related to the VEGF receptors FLT1 and KDR/FLK-1. We have here studied the expression of FLT4 and the other two members of this receptor family in human fetal tissues by Northern and in situ hybridization. These results were also compared with the sites of expression of VEGF and the related placenta growth factor (PlGF). Our results reveal FLT4 mRNA expression in vascular endothelial cells in developing vessels of several organs. A comparison of FLT4, FLT1 and KDR/FLK-1 receptor mRNA signals shows overlapping, but distinct expression patterns in the tissues studied. Certain endothelia lack one or two of the three receptor mRNAs. These data suggest that the receptor tyrosine kinases encoded by the FLT gene family may have distinct functions in the regulation of the growth/differentiation of blood vessels.
引用
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页码:2077 / 2088
页数:12
相关论文
共 50 条
[1]  
APRELIKOVA O, 1992, CANCER RES, V52, P746
[2]   EXPRESSION OF THE VASCULAR-PERMEABILITY FACTOR VASCULAR ENDOTHELIAL GROWTH-FACTOR GENE IN CENTRAL-NERVOUS-SYSTEM NEOPLASMS [J].
BERKMAN, RA ;
MERRILL, MJ ;
REINHOLD, WC ;
MONACCI, WT ;
SAXENA, A ;
CLARK, WC ;
ROBERTSON, JT ;
ALI, IU ;
OLDFIELD, EH .
JOURNAL OF CLINICAL INVESTIGATION, 1993, 91 (01) :153-159
[3]   VASCULAR-PERMEABILITY FACTOR (VASCULAR ENDOTHELIAL GROWTH-FACTOR) GENE IS EXPRESSED DIFFERENTIALLY IN NORMAL-TISSUES, MACROPHAGES, AND TUMORS [J].
BERSE, B ;
BROWN, LF ;
VANDEWATER, L ;
DVORAK, HF ;
SENGER, DR .
MOLECULAR BIOLOGY OF THE CELL, 1992, 3 (02) :211-220
[4]  
BONTHRON DT, 1986, NUCLEIC ACIDS RES, V141, P7125
[5]  
BREIER G, 1992, DEVELOPMENT, V114, P521
[6]   EXPRESSION OF VASCULAR-PERMEABILITY FACTOR (VASCULAR ENDOTHELIAL GROWTH-FACTOR) BY EPIDERMAL-KERATINOCYTES DURING WOUND-HEALING [J].
BROWN, LF ;
YEO, KT ;
BERSE, B ;
YEO, TK ;
SENGER, DR ;
DVORAK, HF ;
VANDEWATER, L .
JOURNAL OF EXPERIMENTAL MEDICINE, 1992, 176 (05) :1375-1379
[7]  
CHARNOCK EL, 1973, PEDIATR CLIN N AM, V20, P275
[8]   PURIFICATION OF A GLYCOPROTEIN VASCULAR ENDOTHELIAL-CELL MITOGEN FROM A RAT GLIOMA-DERIVED CELL-LINE [J].
CONN, G ;
SODERMAN, DD ;
SCHAEFFER, MT ;
WILE, M ;
HATCHER, VB ;
THOMAS, KA .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) :1323-1327
[9]   THE FMS-LIKE TYROSINE KINASE, A RECEPTOR FOR VASCULAR ENDOTHELIAL GROWTH-FACTOR [J].
DEVRIES, C ;
ESCOBEDO, JA ;
UENO, H ;
HOUCK, K ;
FERRARA, N ;
WILLIAMS, LT .
SCIENCE, 1992, 255 (5047) :989-991
[10]  
DUMONT DJ, 1992, ONCOGENE, V7, P1471