P60(V-SRC) CAUSES TYROSINE PHOSPHORYLATION AND INACTIVATION OF THE N-CADHERIN CATENIN CELL-ADHESION SYSTEM

被引：421

作者：

HAMAGUCHI, M ^{[1
]}

MATSUYOSHI, N ^{[1
]}

OHNISHI, Y ^{[1
]}

GOTOH, B ^{[1
]}

TAKEICHI, M ^{[1
]}

NAGAI, Y ^{[1
]}

机构：

[1] KYOTO UNIV, FAC SCI, DEPT BIOPHYS, SAKYO KU, KYOTO 60611, JAPAN

来源：

EMBO JOURNAL | 1993年 / 12卷 / 01期

关键词：

CADHERIN; CATENIN; P60(V-SRC); TRANSFORMATION; TYROSINE PHOSPHORYLATION;

D O I：

10.1002/j.1460-2075.1993.tb05658.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Transformation of chick embryonic fibroblasts with Rous sarcoma virus strongly suppresses N-cadherin-mediated cell-cell adhesion, without inhibiting its expression. This suppression is correlated with tyrosine phosphorylation of N-cadherin and catenins, the cadherin-associated proteins, which are known to regulate cadherin function. Experiments with non-myristylation and temperature-sensitive mutants of RSV and with herbimycin A, a potent inhibitor of tyrosine kinases, suggest that both the suppression of cell adhesion and tyrosine phosphorylation of catenins are highly transformation-specific.

引用

页码：307 / 314

页数：8

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