BETA-ENDORPHIN IS A KIDNEY TROPHIC HORMONE

被引：29

作者：

HADDOX, MK

RUSSELL, DH

机构：

[1] Department of Pharmacology University, Arizona Health Sciences Center Tucson

来源：

LIFE SCIENCES | 1979年 / 25卷 / 07期

关键词：

D O I：

10.1016/0024-3205(79)90556-3

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Intravenous injection of the opioid peptide β-endorphin stimulated an increase in the activity of renal ornithine decarboxylase in rats. The induction of this enzyme is a marker of the growth response of trophic hormone target tissues. Morphine administration promoted an even greater increase in the enzyme activity, which was blocked by the simultaneous administration of the specific opiate antagonist, naloxone. Although hypophysectomy lowered the basal level of ornithine decarboxylase in the kidney, the trophic response to either opioid administration remained intact. This effect of β-endorphin on the kidney may represent a functional role for the circulating endogenous opioid. © 1979.

引用

页码：615 / 620

页数：6

共 19 条

[1]

[Anonymous], 1978, POLYAMINES BIOCH MAR

[2]

BRADFORD M, 1976, ANAL BIOCHEM, V72, P249, DOI DOI 10.1016/0003-2697(76)90527-3)

[3] ORNITHINE DECARBOXYLASE ACTIVITY AND POLYAMINE SYNTHESIS DURING KIDNEY HYPERTROPHY [J].