COMPARATIVE CHROMATIN ANALYSIS OF TRYPANOSOMA-CONGOLENSE

被引：4

作者：

SCHLIMME, W ^{[1
]}

BURRI, M ^{[1
]}

BETSCHART, B ^{[1
]}

HECKER, H ^{[1
]}

机构：

[1] SWISS TROP INST, CH-4002 BASEL, SWITZERLAND

来源：

MEMORIAS DO INSTITUTO OSWALDO CRUZ | 1994年 / 89卷 / 02期

关键词：

TRYPANOSOMA CONGOLENSE; CHROMATIN STRUCTURE; HISTONES; LOWER EUKARYOTES; PROCYCLIC CULTURE FORMS;

D O I：

10.1590/S0074-02761994000200021

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The chromatin of Trypanosoma congolense was analyzed by electron microscopy. The chromatin is organized as nucleosome filaments but does not form a 30 nm fiber. There are five groups of histones, including a histone H1-like protein, which has a molecular weight within the range of the core histones, and is extremely hydrophilic. Weak histone-histone interaction, a typical feature of trypanosome chromatin, was found These results are similar to those for T. cruzi and T. b. brucei, bur differ significantly from those for higher eukaryotes. The results confirm the model of trypanosome chromatin, and support the theory of their early separation from the other eukaryotes during the evolution. T. congolensis is an excellent model for chromatin research on trypanosomes, because it is easy to cultivate and its chromatin has, a relatively high stability, compared to that of other trypanosomes.

引用

页码：227 / 231

页数：5

共 25 条

[1]

ALFAGEME CR, 1974, J BIOL CHEM, V249, P3729

[2] SEQUENCE DIFFERENCES BETWEEN HISTONES OF PROCYCLIC TRYPANOSOMA-BRUCEI-BRUCEI AND HIGHER EUKARYOTES [J].