A HYPOXIC INJURY POTENTIAL IN THE HIPPOCAMPAL SLICE

被引：31

作者：

FAIRCHILD, MD

PARSONS, JE

WASTERLAIN, CG

RINALDI, PC

WALLIS, RA

机构：

[1] VET ADM MED CTR, 16111 PLUMMER ST, SEPULVEDA, CA 91343 USA

[2] UNIV CALIF LOS ANGELES, DEPT NEUROL, LOS ANGELES, CA 90024 USA

[3] UNIV CALIF LOS ANGELES, DEPT PHARMACOL, LOS ANGELES, CA 90024 USA

[4] UNIV CALIF IRVINE, DIV NEUROSURG, IRVINE, CA 92664 USA

来源：

BRAIN RESEARCH | 1988年 / 453卷 / 1-2期

关键词：

D O I：

10.1016/0006-8993(88)90178-3

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

In rat hippocampal slices, neurons in the stratum pyramidale of the CA1 were stimulated orthodromically and antidromically while the resultant extracellular population spikes were monitored. Hypoxic conditions were than induced. After disappearance of the orthodromic population spike, a second orthodromic population spike appeared. We have titled this the hypoxic injury potential since it reflects the onset of permanent injury to neurons in area CA1 of the hippocampus.

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页码：357 / 361

页数：5

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