EVIDENCE FOR A DIFFERENT SENSITIVITY TO VARIOUS CENTRAL EFFECTS OF INTERLEUKIN-1-BETA IN MICE

被引：32

作者：

MASOTTO, C ^{[1
]}

CASPANI, G ^{[1
]}

DESIMONI, MG ^{[1
]}

MENGOZZI, M ^{[1
]}

SCATTURIN, M ^{[1
]}

SIRONI, M ^{[1
]}

CARENZI, A ^{[1
]}

GHEZZI, P ^{[1
]}

机构：

[1] MARIO NEGRI INST PHARMACOL RES,I-20157 MILAN,ITALY

来源：

BRAIN RESEARCH BULLETIN | 1992年 / 28卷 / 02期

关键词：

FOOD INTAKE; WATER INTAKE; INTERLEUKIN; CORTICOSTERONE; GLYCEMIA; CENTRAL NERVOUS SYSTEM; INTRACEREBROVENTRICULAR; INTRAPERITONEAL; MICE;

D O I：

10.1016/0361-9230(92)90175-W

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin 1 (IL-1) induces a series of metabolic and endocrine effects. Activation of the hypothalamus-pituitary-adrenal axis, inhibition of food and water intake, elevation of serum interleukin-6 (IL-6) concentration and hypoglycemia are some of the effects induced by IL-1. The purpose of this study was to compare the sensitivity of these effects following central and peripheral administration of IL-1-beta. Different doses of IL-1-beta (0.1-1000 ng/mouse) were centrally (ICV) or peripherally (IP) injected to male mice two hours prior to sacrifice. The ICV administration was more efficacious than the IP injection in elevating serum corticosterone and IL-6 concentrations, whereas no difference was evident in the IL-1-beta-induced hypoglycemia. Central IL-1-beta-administration was also more potent than IP injection in inhibiting overnight food and water intake. A dose-dependent effect was evident in all these cases. In summary, our data compare effects elicited by central or peripheral administration of different doses of IL-1-beta. This comparison suggests that the IL-1-beta-stimulation of serum corticosterone and IL-6 and inhibition of food and water intake are events more centrally mediated than the IL-1-beta-induced hypoglycemia.

引用

页码：161 / 165

页数：5

共 31 条

[1] BIDIRECTIONAL TRANSPORT OF INTERLEUKIN-1-ALPHA ACROSS THE BLOOD-BRAIN-BARRIER [J].