ANTIBIOTIC MAGAININS EXERT CYTOLYTIC ACTIVITY AGAINST TRANSFORMED-CELL LINES THROUGH CHANNEL FORMATION

被引：363

作者：

CRUCIANI, RA

BARKER, JL

ZASLOFF, M

CHEN, HC

COLAMONICI, O

机构：

[1] NINCDS,NEUROPHYSIOL LAB,BETHESDA,MD 20892

[2] NICHHD,ENDOCRINOL & REPROD RES BRANCH,BETHESDA,MD 20892

[3] CHILDRENS HOSP PHILADELPHIA,DEPT GENET,DIV HUMAN GENET,PHILADELPHIA,PA 19104

[4] CHILDRENS HOSP PHILADELPHIA,DEPT PEDIAT,PHILADELPHIA,PA 19104

[5] UNIV CHICAGO,DEPT MED,HEMATOL ONCOL SECT,CHICAGO,IL 60637

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1991年 / 88卷 / 09期

关键词：

ANTITUMOR; CYTOLYSIS; MAGAININ CHANNELS;

D O I：

10.1073/pnas.88.9.3792

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Magainins are an ionophoric class of vertebrate peptides with antibiotic activity against various microorganisms. Here we show that magainin 2 and synthetic analogues can rapidly and irreversibly lyse hematopoietic tumor and solid tumor target cells with a relative cytotoxic potency that parallels their antibacterial efficacy and at concentrations that are relatively nontoxic to well-differentiated cells. The cytotoxicity is prevented by cell depolarization. Magainins represent a natural cytolytic agent in vertebrates and may provide another therapeutic strategy for certain tumors.

引用

页码：3792 / 3796

页数：5

共 14 条

[1] SYNTHETIC MAGAININ ANALOGS WITH IMPROVED ANTIMICROBIAL ACTIVITY [J].