A POSSIBLE ROLE FOR NONSENSE SUPPRESSION IN THE SYNTHESIS OF A HUMAN CYTOMEGALOVIRUS 58-KDA VIRION PROTEIN

被引：12

作者：

LAHIJANI, RS

OTTESON, EW

STJEOR, SC

机构：

[1] UNIV NEVADA, DEPT MICROBIOL, RENO, NV 89557 USA

[2] UNIV NEVADA, CELL & MOLEC BIOL PROGRAM, RENO, NV 89557 USA

来源：

VIROLOGY | 1992年 / 186卷 / 01期

关键词：

D O I：

10.1016/0042-6822(92)90087-6

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 1.6-kb late mRNA originating from the HindIII R fragment of human cytomegalovirus (HCMV) encodes a 58-kDa virion phosphoprotein. Data presented support the hypothesis that this protein may be synthesized via the translational readthrough of an opal termination codon separating two open reading frames located in tandem. To our knowledge this is the first report of nonsense suppression as a means of regulating gene expression in HCMV. © 1992.

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页码：309 / 312

页数：4

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