TUMOR-NECROSIS-FACTOR-ALPHA IS INVOLVED IN MOUSE GROWTH AND LYMPHOID-TISSUE DEVELOPMENT

被引:65
作者
DEKOSSODO, S
GRAU, GE
DANEVA, T
POINTAIRE, P
FOSSATI, L
ODY, C
ZAPF, J
PIGUET, PF
GAILLARD, RC
VASSALLI, P
机构
[1] UNIV GENEVA,CTR MED UNIV,DEPT PATHOL,CH-1211 GENEVA 4,SWITZERLAND
[2] UNIV HOSP ZURICH,DEPT MED,METAB UNIT,CH-8091 ZURICH,SWITZERLAND
[3] UNIV GENEVA,HOP CANTONAL,DEPT MED,NEUROENDOCRINE UNIT,CH-1211 GENEVA 4,SWITZERLAND
关键词
D O I
10.1084/jem.176.5.1259
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Tumor necrosis factor alpha (TNF-alpha), a major mediator of inflammation, also possesses a wide pleiotropism of actions, suggesting its involvement in physiological conditions. TNF-alpha mRNA is present in mouse embryonic tissues and also in fetal thymus and spleen. Repeated injections of a monospecific polyclonal rabbit anti-mouse TNF-alpha antibody in mice, starting either during pregnancy or at birth, led to a severe but transient growth retardation, already present at birth, reaching a 35% decrease in body weight at 3 wk, with complete recovery at 8 wk. The insulin growth factor I (IGF-I) blood levels were decreased to about 50%; growth hormone release and other endocrine functions were unaltered. A marked atrophy of the thymus, spleen, and lymph nodes was also observed, with lymphopenia and impaired development of T and B cell peripheral lymphoid structures. The pathways involving TNF-alpha in IGF-I release and early body growth are probably distinct from those by which TNF-alpha participates in early development of lymphoid tissues, where its low physiological release may contribute to enhance lymphoid cell expansion.
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收藏
页码:1259 / 1264
页数:6
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