REARRANGEMENTS AND ABERRANT EXPRESSION OF THE RETINOIC ACID RECEPTOR-ALPHA GENE IN ACUTE PROMYELOCYTIC LEUKEMIAS

被引：204

作者：

LONGO, L

PANDOLFI, PP

BIONDI, A

RAMBALDI, A

MENCARELLI, A

COCO, FL

DIVERIO, D

PEGORARO, L

AVANZI, G

TABILIO, A

ZANGRILLI, D

ALCALAY, M

DONTI, E

GRIGNANI, F

PELICCI, PG

机构：

[1] UNIV PERUGIA,MONTELUCE POLICLIN,IST CLIN MED 1,I-06100 PERUGIA,ITALY

[2] UNIV MILAN,OSPED S GERARDO,PEDIAT CLIN,I-20052 MONZA,ITALY

[3] OSPED RIUNITI BERGAMO,DIV EMATOL,I-24100 BERGAMO,ITALY

[4] IST RIC FARMACOL M NEGRI,I-24100 BERGAMO,ITALY

[5] UNIV ROME 1,DIV EMATOL,I-00161 ROME,ITALY

[6] UNIV TURIN,OSPED MAGGIORE S GIOVANNI,IST MED INTERNA,I-10126 TURIN,ITALY

[7] UNIV ROME 2,CATTEDRA EMATOL,DIPARTIMENTO MED INTERNA,I-00100 ROME,ITALY

来源：

JOURNAL OF EXPERIMENTAL MEDICINE | 1990年 / 172卷 / 06期

关键词：

D O I：

10.1084/jem.172.6.1571

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Although acute promyelocytic leukemias (APLs) are consistently associated with a reciprocal chromosome 15;17 translocation, the gene(s) directly affected by the breakpoints have never been isolated. The chromosome 17 breakpoint maps to near the retinoic acid receptor α (RARα) locus. Investigation of20 APLs and a large series ofother neoplastic patients and normal controls revealed RARα gene rearrangements and aberrant transcripts only in the APL cases. These findings suggest that the RARα gene is involved in the APL chromosome 17 breakpoint, is implicated in leukemogenesis, and could be used as a marker for identifying leukemic promyelocytes. © 1990, Rockefeller University Press., All rights reserved.

引用

页码：1571 / 1575

页数：5

共 15 条

[1] C-ABL AND BCR ARE REARRANGED IN A PH1-NEGATIVE CML PATIENT [J].