ACUTE MYELOBLASTIC-LEUKEMIA (M2) WITH TRANSLOCATION(7-11) FOLLOWED BY MARKED EOSINOPHILIA AND ADDITIONAL ABNORMALITIES OF CHROMOSOME-5

被引：17

作者：

ABE, A ^{[1
]}

TANIMOTO, M ^{[1
]}

TOWATARI, M ^{[1
]}

MATSUOKA, A ^{[1
]}

KITAORI, K ^{[1
]}

KATO, H ^{[1
]}

TOYOZUMI, H ^{[1
]}

TAKEO, T ^{[1
]}

ADACHI, K ^{[1
]}

EMI, N ^{[1
]}

KAWASHIMA, K ^{[1
]}

SAITO, H ^{[1
]}

机构：

[1] MEITETSU HOSP, NAGOYA, AICHI, JAPAN

来源：

CANCER GENETICS AND CYTOGENETICS | 1995年 / 83卷 / 01期

关键词：

D O I：

10.1016/S0165-4608(95)00021-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We present an 18-year-old woman who was diagnosed with acute myeloblastic leukemia (AML M2), and in whom chromosome analysis of bone marrow cells revealed t(7;11), on abnormality rarely found in leukemias with a differentiation potency. She relapsed 1 year after complete remission was achieved by chemotherapy. Bone marrow examination then revealed a t(7;11) abnormality in 48 of 50 metaphases examined, even when there were less than 7.5% leukemic blasts in the marrow, indicating that the morphologically normal cells were derived from leukemic blasts. The number of leukemia clones with the additional abnormalities in chromosome 5 increased, with concurrent development of eosinophilia, fever, asthma-like symptoms, erythema, itching, and hepatosplenomegaly. Elevation of interleukin 5 (IL-5) in serum and an enhanced expression of IL-5 mRNA were also detected. The increase in IL-5 may have been produced by on abnormality on chromosome 5.

引用

页码：37 / 41

页数：5

共 23 条

[1]

BHAMBHANI K, 1986, CANCER GENET CYTOGEN, V14, P371

[2] A MYELOPROLIFERATIVE DISEASE IN 2 INFANTS ASSOCIATED WITH EOSINOPHILIA AND CHROMOSOME-T(1-5) TRANSLOCATION [J].