CELLULAR RETINOIC ACID-BINDING PROTEIN TYPE-2 MESSENGER-RNA IS OVEREXPRESSED IN HUMAN PSORIATIC SKIN AS SHOWN BY INSITU HYBRIDIZATION

被引:24
作者
DIDIERJEAN, L [1 ]
DURAND, B [1 ]
SAURAT, JH [1 ]
机构
[1] CNRS,INSERM,U184,LGME,STRASBOURG,FRANCE
关键词
D O I
10.1016/S0006-291X(05)81277-X
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In situ hybridization with full length mouse cellular retinoic acid-binding protein type 1 and cellular retinoic acid-binding protein type 2 cDNA derived RNA probes showed overexpression of cellular retinoic acid-binding protein type 2 mRNA in lesional hyperplastic psoriatic skin whereas cellular retinoic acid-binding protein type 1 mRNA was undetectable. This suggests that the previously reported increase of cellular retinoic acid-binding protein in psoriatic epidermis corresponds to increased translation of cellular retinoic acid-binding protein type 2 gene. Cellular retinoic acid-binding protein types 1 and 2 mRNAs were not detectable in normal epidermis; however, type 2 message was detected in non hyperplastic, non lesional skin of psoriatic patients thus before altered epidermal differentiation and hyperplasia are morphologically detectable. © 1991 Academic Press, Inc.
引用
收藏
页码:204 / 208
页数:5
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