ATP-SENSITIVE K-CHANNELS IN HEART-MUSCLE - SPARE CHANNELS

被引：70

作者：

FINDLAY, I

FAIVRE, JF

机构：

[1] Laboratoire de Physiologie Comparée (URA CNRS 1121), Université de Paris XI, Orsay

来源：

FEBS LETTERS | 1991年 / 279卷 / 01期

关键词：

K-CHANNEL; LIGAND SENSITIVITY; ATP; RAT VENTRICULAR MUSCLE;

D O I：

10.1016/0014-5793(91)80259-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We show that ATP-sensitive K+ channels of excised inside-out membrane patches of rat ventricular myocytes show considerable variation in their sensitivity to ATP. In 102 different membrane patches IC50 values ranged from 9 to 580 mu-M ATP and Hill coefficients from 1% to 6.41% of patches showed openings of ATP-sensitive K+ channels in the presence of 1 mM ATP. These results considerably widen the range of internal ATP concentrations over which one might expect activation of the ATP-sensitive K+ current in cardiac myocytes.

引用

页码：95 / 97

页数：3

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