ABSORPTION OF UNALTERED FOLIC ACID FROM GASTRO-INTESTINAL TRACT IN MAN

被引：84

作者：

WHITEHEAD, VM

COOPER, BA

机构：

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1967年 / 13卷 / 05期

关键词：

D O I：

10.1111/j.1365-2141.1967.tb08833.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Hepatic portal and systemic plasma folate levels were determined in human subjects during umbilical-vein catheterization after oral administration of folic acid. Hepatic-vein blood was obtained during right heart catheterization. Serial folate measurements with Lactobacillus casei and Streptococcus fecalis and TEAE [triethylaminoethyl]-cellulose chromatography revealed that folic acid is rapidly absorbed into the portal blood without undergoing metabolic conversion. A delay in rise in folate levels in systemic and hepatic-vein blood, together with the finding of large amounts of folic acid and methylfolatein blood subsequently leaving the liver, indicates that this organ is the major site of folic-acid metabolism.

引用

页码：679 / +

页数：1

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