AGING AND PROTEIN OXIDATIVE DAMAGE

被引:67
作者
AGARWAL, S [1 ]
SOHAL, RS [1 ]
机构
[1] SO METHODIST UNIV,DEPT BIOL SCI,DALLAS,TX 75275
关键词
PROTEIN OXIDATION; AGING; FREE RADICALS; OXYGEN RADICALS; OXIDATIVE DAMAGE;
D O I
10.1016/0047-6374(94)90024-8
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The hypothesis that aging is associated with the accumulation of oxidative damage was tested in the adult male housefly by monitoring the loss of membrane protein -SH groups, and activities of glucosed-phosphate dehydrogenase and alcohol dehydrogenase, the cytosolic enzymes that are particularly susceptible to oxidative damage. Membrane protein -SH content and activities of these enzymes decreased with age and were correlated with the life expectancy or physiological age rather than the chronological age of the flies. Because the experimentally-induced loss of membrane protein -SH groups has a demonstrable deleterious effect on a variety of cellular functions, such damage during aging can be hypothesized to contribute to the physiological attrition associated with senescence.
引用
收藏
页码:11 / 19
页数:9
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