ADENOVIRUS TYPE-5 EARLY GENE-FUNCTION REGULATES EXPRESSION OF OTHER EARLY VIRAL GENES

被引：723

作者：

JONES, N ^{[1
]}

SHENK, T ^{[1
]}

机构：

[1] UNIV CONNECTICUT,CTR HLTH,DEPT MICROBIOL,FARMINGTON,CT 06032

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 08期

关键词：

D O I：

10.1073/pnas.76.8.3665

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We have identified an adenovirus type 5 (Ad5) early gene function located in early region I which is required for the production of early cytoplasmic mRNAs corresponding to early regions 2, 3, and 4. Mutant dl312 (lacks the segment between 1.5 and 4.5 map units) grows as well as wild-type virus in 293 cells (Ad5-transformed human in embryonic kidney cells), but its growth is severely restricted in HeLa cells. We detect no viral RNAs in the cytoplasm of dl312-infected HeLa cells. Viral RNA sequences are present, however, in dl312-infected HeLa cell nuclei.

引用

页码：3665 / 3669

页数：5

共 24 条

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