REVERSIBLE BINDING AND INHIBITION OF CATALASE BY NITRIC-OXIDE

被引：262

作者：

BROWN, GC

机构：

[1] Department of Biochemistry, University of Cambridge

来源：

EUROPEAN JOURNAL OF BIOCHEMISTRY | 1995年 / 232卷 / 01期

关键词：

NITRIC OXIDE; CATALASE; CYTOTOXICITY; HYDROGEN PEROXIDE;

D O I：

10.1111/j.1432-1033.1995.tb20798.x

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The interactions between nitric oxide (NO), H2O2, and catalase were investigated. H2O2 did not cause detectable breakdown of NO in the absence of catalase, but did cause NO breakdown in the presence of catalase. Catalase bound NO, and NO rapidly and reversibly inhibited catalase with a K-i of 0.18 mu M. The significance of these results for NO cytotoxicity is discussed.

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页码：188 / 191

页数：4

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