ANONYMOUS MARKERS LOCATED ON CHROMOSOME-6 IN THE HLA-A CLASS-I REGION - ALLELIC DISTRIBUTION IN GENETIC HEMOCHROMATOSIS

被引：31

作者：

BORETTO, J

JOUANOLLE, AM

YAOUANQ, J

ELKAHLOUN, A

MAUVIEUX, V

BLAYAU, M

PERICHON, M

LETREUT, A

CLAYTON, J

BOROT, N

LEGALL, JY

PONTAROTTI, P

DAVID, V

机构：

[1] FAC MED RENNES, BIOCHIM MED B LAB, F-35043 RENNES, FRANCE

[2] CNRS, INSERM, CTR IMMUNOL, F-13288 MARSEILLE 9, FRANCE

[3] CHU RENNES, MED F CHU, F-35000 RENNES, FRANCE

[4] CHU PURPAN, CNRS, UPR 8291, F-31300 TOULOUSE, FRANCE

来源：

HUMAN GENETICS | 1992年 / 89卷 / 01期

关键词：

D O I：

10.1007/BF00207038

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two yeast artificial chromosomes of the HLA class I region were subcloned. Four of the subclones studied displayed restriction polymorphisms that corresponded to six bi-allelic series. Allelic distribution of the anonymous markers was then studied by comparing a control population with a group of patients with familial haemochromatosis. Only one marker presents an unequivocal association with the haemochromatosis gene and is 100 kb centromeric to HLA-A. This association however is not as strong as with HLA-A3. The results suggest two possible locations for the haemochromatosis gene: less than 100 kb centromeric to the HLA-A locus, or on the telomeric side.

引用

页码：33 / 36

页数：4

共 22 条

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