ON THE MODE OF ACTION OF LFA-1

被引：222

作者：

FIGDOR, CG ^{[1
]}

VANKOOYK, Y ^{[1
]}

KEIZER, GD ^{[1
]}

机构：

[1] HOLLAND BIOTECHNOL, LEIDEN, NETHERLANDS

来源：

IMMUNOLOGY TODAY | 1990年 / 11卷 / 08期

关键词：

D O I：

10.1016/0167-5699(90)90112-M

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The leukocyte function-associated molecule 1 (LFA-1) plays a key role in cell adhesion among leukocytes and between leukocytes and other cell types. Although two ligands of LFA-1 have been identified, namely the intercellular adhesion molecules 1 (ICAM-1) and 2 (ICAM-2), the exact mechanism by which LFA-1 binds to and detaches from its ligand(s) has remained obscure. Based on novel findings Carl Figdor, Yvette van Kooyk and Gerrit Keizer now present a model of LFA-1-mediated lymphocyte adhesion, showing that LFA-1-dependent cell adhesion is a dynamic process in which ligand-binding affinity is regulated by intramolecular changes in LFA-1. This process is controlled by other lymphocyte surface structures, notably CD2 and CD3. © 1990.

引用

页码：277 / 280

页数：4

共 41 条

[1] KINASES AND PHOSPHATASES IN T-CELL ACTIVATION [J].