LATERAL DIFFUSION IN BINARY-MIXTURES OF CHOLESTEROL AND PHOSPHATIDYLCHOLINES

被引：331

作者：

RUBENSTEIN, JR ^{[1
]}

SMITH, BA ^{[1
]}

MCCONNELL, HM ^{[1
]}

机构：

[1] STANFORD UNIV, STAUFFER LAB PHYS CHEM, STANFORD, CA 94305 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1979年 / 76卷 / 01期

关键词：

D O I：

10.1073/pnas.76.1.15

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The lateral diffusion of a fluorescent-labeled phospholipid, phosphatidyl-N-(4-nitrobenzo-2-oxa-1,3,-diazole)ethanolamine, has been measured in binary mixtures of cholesterol and dimyristoyl phosphatidylcholine at temperatures both above and below 23.8 degrees C, the chain-melting transition temperature of this phosphatidylcholine. There is a temperature-composition region, approximately temperature less than 23 degrees C and mole fraction of cholesterol (X) less than 0.20, in which the lateral diffusion coefficient of the fluorescent probe is at least an order of magnitude smaller than it is at points outside of this temperature-composition region. At temperatures above approximately 23 degrees C there is a significant increasing cholesterol concentration, for X greater than 0.2.

引用

页码：15 / 18

页数：4

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