(6S)-6-FLUOROSHIKIMIC ACID, AN ANTIBACTERIAL AGENT ACTING ON THE AROMATIC BIOSYNTHETIC-PATHWAY

被引：111

作者：

DAVIES, GM ^{[1
]}

BARRETTBEE, KJ ^{[1
]}

JUDE, DA ^{[1
]}

LEHAN, M ^{[1
]}

NICHOLS, WW ^{[1
]}

PINDER, PE ^{[1
]}

THAIN, JL ^{[1
]}

WATKINS, WJ ^{[1
]}

WILSON, RG ^{[1
]}

机构：

[1] ZENECA PHARMACEUT,DEPT INFECT RES,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 02期

关键词：

D O I：

10.1128/AAC.38.2.403

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

(6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 mu g ml(-1)), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight(-1)). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine.

引用

页码：403 / 406

页数：4

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