RAF MEETS RAS - COMPLETING THE FRAMEWORK OF A SIGNAL-TRANSDUCTION PATHWAY

被引：546

作者：

AVRUCH, J

ZHANG, XF

KYRIAKIS, JM

机构：

[1] MASSACHUSETTS GEN HOSP,MED SERV,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,DEPT MED,BOSTON,MA 02114

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1994年 / 19卷 / 07期

关键词：

D O I：

10.1016/0968-0004(94)90005-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Ras oncoprotein, a GTP-activated molecular switch, interacts directly with the Raf oncoprotein to recruit the MAP kinases and their subordinates. In this way, a mitogenic signal initiated by tyrosine kinases is converted by Ras into a wave of regulatory phosphorylation on serine and threonine residues that, depending on its intensity and duration, and the variety of substrates available, results in cell differentiation or cell division.

引用

页码：279 / 283

页数：5

共 43 条

[1]

Ahn Natalie G., 1992, Current Opinion in Cell Biology, V4, P992, DOI 10.1016/0955-0674(92)90131-U

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