MELATONIN STIMULATES BRAIN GLUTATHIONE-PEROXIDASE ACTIVITY

被引：525

作者：

BARLOWWALDEN, LR ^{[1
]}

REITER, RJ ^{[1
]}

ABE, M ^{[1
]}

PABLOS, M ^{[1
]}

MENENDEZPELAEZ, A ^{[1
]}

CHEN, LD ^{[1
]}

POEGGELER, B ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,DEPT CELLULAR & STRUCT BIOL,SAN ANTONIO,TX 78284

来源：

NEUROCHEMISTRY INTERNATIONAL | 1995年 / 26卷 / 05期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/0197-0186(94)00154-M

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Exogenously administered melatonin causes a 2-fold rise in glutathione peroxidase activity within 30 min in the brain of the rat. Furthermore, brain glutathione peroxidase activity is higher at night than during the day and is correlated with high night-time tissue melatonin levels. Glutathione peroxidase is thought to be the principal enzyme eliminating peroxides in the brain. This antioxidative enzyme reduces the formation of hydroxyl hydroxyl radicals formed via iron-catalyzed Fenton-type reactions from hydrogen peroxide by reducing this oxidant to water. Since the hydroxyl radical is the most noxious oxygen radical known, induction of brain glutathione peroxidase might be an important mechanism by which melatonin exerts its potent neuroprotective effects.

引用

页码：497 / 502

页数：6

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