A DOSAGE SENSITIVE LOCUS AT CHROMOSOME XP21 IS INVOLVED IN MALE TO FEMALE SEX REVERSAL

被引：528

作者：

BARDONI, B

ZANARIA, E

GUIOLI, S

FLORIDIA, G

WORLEY, KC

TONINI, G

FERRANTE, E

CHIUMELLO, G

MCCABE, ERB

FRACCARO, M

ZUFFARDI, O

CAMERINO, G

机构：

[1] UNIV PAVIA, I-27100 PAVIA, ITALY

[2] BAYLOR COLL MED, DEPT MOLEC & HUMAN GENET, HOUSTON, TX 77030 USA

[3] UNIV ROMA LA SAPIENZA, IST CLIN PEDIAT, I-00161 ROME, ITALY

[4] HOSP SAN RAFFAELE, I-20132 MILAN, ITALY

[5] UNIV SASSARI, IST ISTOL & EMBRIOL, I-07100 SASSARI, ITALY

来源：

NATURE GENETICS | 1994年 / 7卷 / 04期

关键词：

D O I：

10.1038/ng0894-497

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Male to female sex reversal has been observed in individuals with duplications of the short arm of the X chromosome. Here we demonstrate that sex reversal results from the presence of two active copies of an Xp locus rather than from its rearrangement and that alterations at this locus constitute one of the causes of sex reversal in individuals with a normal 46,XY karyotype. We have named this locus DSS (Dosage Sensitive Sex reversal) and localized it to a 160 kilobase region of chromosome Xp21, adjacent to the adrenal hypoplasia congenita locus. The identification of male individuals deleted for DSS suggests that this locus is not required for testis differentiation. We propose that DSS has a role in ovarian development and/or functions as a link between ovary and testis formation.

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页码：497 / 501

页数：5

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