EFFECTOR FUNCTIONS OF ACTIVATED MACROPHAGES AGAINST PARASITES

被引：59

作者：

JAMES, SL ^{[1
]}

NACY, C ^{[1
]}

机构：

[1] ENTREMED INC, ROCKVILLE, MD 20850 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 1993年 / 5卷 / 04期

关键词：

D O I：

10.1016/0952-7915(93)90032-N

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Evidence in experimental animals indicates a major role for cytokine-activated macrophages as effector cells in protective immunity against parasites. Research on cytokine function during this past year has contributed many insights into the immune mechanisms regulating murine macrophage function as well as the effector molecules employed by these cells to kill both intracellular and extracellular parasites.

引用

收藏

页码：518 / 523

页数：6

相关论文

共 55 条

[1] GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR INCREASES THE INFECTIVITY OF LEISHMANIA-AMAZONENSIS BY PROTECTING PROMASTIGOTES FROM HEAT-INDUCED DEATH [J].

BARCINSKI, MA ;

SCHECHTMAN, D ;

QUINTAO, LG ;

COSTA, DD ;

SOARES, LRB ;

MOREIRA, MEC ;

CHARLAB, R .

INFECTION AND IMMUNITY, 1992, 60 (09) :3523-3527

[2] TRANSFORMING GROWTH-FACTOR-BETA IN LEISHMANIAL INFECTION - A PARASITE ESCAPE MECHANISM [J].

BARRALNETTO, M ;

BARRAL, A ;

BROWNELL, CE ;

SKEIKY, YAW ;

ELLINGSWORTH, LR ;

TWARDZIK, DR ;

REED, SG .

SCIENCE, 1992, 257 (5069) :545-548

[3] SOLUBLE TNF AND MEMBRANE TNF EXPRESSED ON CD4+T LYMPHOCYTES DIFFER IN THEIR ABILITY TO ACTIVATE MACROPHAGE ANTILEISHMANIAL DEFENSE [J].

BIRKLAND, TP ;

SYPEK, JP ;

WYLER, DJ .

JOURNAL OF LEUKOCYTE BIOLOGY, 1992, 51 (03) :296-299

[4] MACROPHAGE DEACTIVATION BY INTERLEUKIN-10 [J].

BOGDAN, C ;

VODOVOTZ, Y ;

NATHAN, C .

JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06) :1549-1555

[5] IMMUNITY TO HELMINTHS - READY TO TIP THE BIOCHEMICAL BALANCE [J].

BROPHY, PM ;

PRITCHARD, DI .

PARASITOLOGY TODAY, 1992, 8 (12) :419-422

[6] MACROPHAGE ACTIVATION FOR INTRACELLULAR KILLING AS INDUCED BY A CA2+ IONOPHORE - DEPENDENCE ON L-ARGININE-DERIVED NITROGEN OXIDATION-PRODUCTS [J].

BUCHMULLERROUILLER, Y ;

CORRADIN, SB ;

MAUEL, J .

BIOCHEMICAL JOURNAL, 1992, 284 :387-392

[7] INDUCTION OF TUMOR-NECROSIS-FACTOR-ALPHA BY LEISHMANIA-INFANTUM IN MURINE MACROPHAGES FROM DIFFERENT INBRED MICE STRAINS [J].

CHIOFALO, MS ;

DELFINO, D ;

MANCUSO, G ;

LATASSA, E ;

MASTROENI, P ;

IANNELLO, D .

MICROBIAL PATHOGENESIS, 1992, 12 (01) :9-17

[8]

CORRADIN SB, 1991, J IMMUNOL, V146, P279

[9] INTERLEUKIN-10 (IL-10) INHIBITS THE INDUCTION OF NITRIC-OXIDE SYNTHASE BY INTERFERON-GAMMA IN MURINE MACROPHAGES [J].

CUNHA, FQ ;

MONCADA, S ;

LIEW, FY .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1992, 182 (03) :1155-1159

[10] ACTIVATED MOUSE MACROPHAGES KILL ENTAMOEBA-HISTOLYTICA TROPHOZOITES BY RELEASING REACTIVE NITROGEN INTERMEDIATES [J].

DENIS, M ;

GHADIRIAN, E .

MICROBIAL PATHOGENESIS, 1992, 12 (03) :193-198

← 1 2 3 4 5 6 →