OSMOTIC BLOOD-BRAIN-BARRIER DISRUPTION - COMPUTERIZED TOMOGRAPHIC MONITORING OF CHEMOTHERAPEUTIC AGENT DELIVERY

被引：115

作者：

NEUWELT, EA

MARAVILLA, KR

FRENKEL, EP

RAPOPORT, SI

HILL, SA

BARNETT, PA

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT RADIOL,DALLAS,TX 75235

[2] UNIV TEXAS,HLTH SCI CTR,SW MED SCH,DEPT INTERNAL MED,DALLAS,TX 75235

[3] NIH,BETHESDA,MD 20205

来源：

JOURNAL OF CLINICAL INVESTIGATION | 1979年 / 64卷 / 02期

关键词：

D O I：

10.1172/JCI109509

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The present study describes a canine model of transient reversible blood-brain barrier disruption with hyperosmolar mannitol infusion into the internal carotid artery. Studies in this model show that osmotic blood-brain barrier disruption before intracarotid infusion of methotrexate results in markedly elevated (therapeutic) levels of drug in the ipsilateral cerebral hemisphere. Levels in the cerebrospinal fluid correlate poorly and inconsistently with brain levels. Computerized tomograms in this canine model provide a noninvasive monitor of the degree, time-course and localization of osmotic blood-brain barrier disruption.

引用

页码：684 / 688

页数：5

共 15 条

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2-M

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ACTA RADIOLOGICA-DIAGNOSIS, 1974, 15 (01) :21-32

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