FOWLPOX VIRUS RECOMBINANT ENCODING THE MEASLES-VIRUS FUSION PROTEIN - PROTECTION OF MICE AGAINST FATAL MEASLES ENCEPHALITIS

被引：27

作者：

WILD, F

GIRAUDON, P

SPEHNER, D

DRILLIEN, R

LECOCQ, JP

机构：

[1] TRANSGENE SA,11 RUE MOLSHEIM,F-67000 STRASBOURG,FRANCE

[2] UNIV CLAUDE BERNARD LYON 1,CNRS,F-69372 LYONS 08,FRANCE

[3] UNIV STRASBOURG 1,VIROL LAB,INSERM,U74,F-67070 STRASBOURG,FRANCE

来源：

VACCINE | 1990年 / 8卷 / 05期

关键词：

ELISA; Fowlpox virus; measles virus; mice;

D O I：

10.1016/0264-410X(90)90243-F

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A recombinant Fowlpox virus engineered to encode the measles virus fusion protein was shown to protect mice against a challenge measles infection. A vaccine dose of about 106 p.f.u. was needed to protect nearly 100% of the animals. Mice failed to develop a significant level of antibodies directed against measles virus suggesting that other components of the immune system may be involved. © 1990.

引用

页码：441 / 442

页数：2

共 6 条

[1] CONSTRUCTION OF RECOMBINANT FOWLPOX VIRUSES AS VECTORS FOR POULTRY VACCINES [J].