TELOMERE POSITIONAL EFFECTS AND THE REGULATION OF CELLULAR SENESCENCE

被引：238

作者：

WRIGHT, WE

SHAY, JW

机构：

[1] Department of Cell Biology and Neuroscience, University of Texas Southwestern Medical Center, Dallas, TX 75235-9039

来源：

TRENDS IN GENETICS | 1992年 / 8卷 / 06期

关键词：

D O I：

10.1016/0168-9525(92)90232-S

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Normal cells have a limited capacity to proliferate but the molecular clock that regulates the onset of cellular senescence remains unidentified. The ends of chromosomes - telomeres - have been shown to shorten progressively with age in normal cells. Here, we present a working model of how telomeric shortening may induce programmed changes in the regulation of cellular proliferation.

引用

页码：193 / 197

页数：5

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