LONG-TERM SYNAPSE LESS INDUCED BY FOCAL BLOCKADE OF POSTSYNAPTIC RECEPTORS

被引：226

作者：

BALICEGORDON, RJ ^{[1
]}

LICHTMAN, JW ^{[1
]}

机构：

[1] WASHINGTON UNIV,SCH MED,DEPT ANAT & NEUROBIOL,ST LOUIS,MO 63110

来源：

NATURE | 1994年 / 372卷 / 6506期

关键词：

D O I：

10.1038/372519a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Focal application in vivo of alpha-bungarotoxin to block neurotransmission in a small region of a neuromuscular junction causes long-lasting synapse elimination at that site. In contrast, blockade of neurotransmission throughout a junction does not cause synapse elimination. These and related experiments indicate that active synaptic sites can destabilize inactive synapses in their vicinity.

引用

页码：519 / 524

页数：6

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