DISSOLUTION OF COMMERCIAL ASPIRIN

被引：33

作者：

MITCHELL, AG

SAVILLE, DJ

机构：

[1] Faculty of Pharmacy, University of British Columbia, British Columbia

[2] The Pharmacy Department, University of Sydney, Sydney, New South Wales

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1969年 / 21卷 / 01期

关键词：

D O I：

10.1111/j.2042-7158.1969.tb08126.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Two samples of commercial aspirin showing a difference in intrinsic dissolution rate have been studied. Crystallographic examination and solubility determinations failed to reveal any difference between them. The effects of agitation and temperature on intrinsic dissolution rates showed that the samples had different thermodynamic activities and, depending on the conditions, the metastable form was capable of rapid reversion to a more stable form. 1969 Royal Pharmaceutical Society of Great Britain

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页码：28 / &

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