INTERLEUKIN-6, A POSSIBLE AUTOCRINE GROWTH AND DIFFERENTIATION FACTOR FOR THE HUMAN MEGAKARYOCYTIC CELL-LINE, CMK

被引：33

作者：

FUSE, A ^{[1
]}

KAKUDA, H ^{[1
]}

SHIMA, Y ^{[1
]}

VANDAMME, J ^{[1
]}

BILLIAU, A ^{[1
]}

SATO, T ^{[1
]}

机构：

[1] CHIBA UNIV,SCH MED,DEPT MICROBIOL & PEDIAT,CHIBA,JAPAN

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 1991年 / 77卷 / 01期

关键词：

D O I：

10.1111/j.1365-2141.1991.tb07944.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

CMK is a human cell line derived from a megakaryoblastic leukaemia. It has characteristics of the megakaryocytic lineage, such as the presence of platelet peroxidase, membrane glycoproteins (GP)Ib and GPIIb/IIIa, alpha-granules, and demarcation membranes. The cell line proliferates autonomously in serum-containing medium. Here we report that the cell line expresses the gene for IL-6 and releases small quantities of the cytokine into the medium. Addition of exogenous IL-6 to cultures seeded into medium was found to promote growth of the cells. Conversely, addition of a neutralizing anti-IL-6 antibody inhibited cell growth. These data support the notion that autocrine IL-6 is one of the factors accounting for autonomous growth of the cell line.

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页码：32 / 36

页数：5

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