ASSAY OF PYROGENS BY INTERLEUKIN-6 RELEASE FROM MONOCYTIC CELL-LINES

被引：90

作者：

TAKTAK, YS ^{[1
]}

SELKIRK, S ^{[1
]}

BRISTOW, AF ^{[1
]}

CARPENTER, A ^{[1
]}

BALL, C ^{[1
]}

RAFFERTY, B ^{[1
]}

POOLE, S ^{[1
]}

机构：

[1] NATL INST BIOL STAND & CONTROLS,DEPT ENDOCRINOL,BLANCHE LANE,POTTERS BAR EN6 3QG,HERTS,ENGLAND

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1991年 / 43卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1991.tb03540.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A novel in-vitro system has been developed for the detection and quantification of pyrogen in pharmaceutical products. The measured variable was evoked secretion of the pyrogenic cytokine interleukin-6 from MONO MAC 6 monocytic cells incubated with the product. The interleukin-6 was detected using a specific and sensitive ELISA developed for this purpose. The test system detected pyrogenic contamination in 3 batches of therapeutic human serum albumin which had caused adverse reactions in recipients. The contamination was not detected in conventional tests: the rabbit pyrogen test and the limulus amoebocyte lysate test.

引用

页码：578 / 582

页数：5

共 13 条

[1]

AREND WP, 1989, J IMMUNOL, V143, P118

[2] HUMAN LEUKOCYTIC PYROGEN TEST FOR DETECTION OF PYROGENIC MATERIAL IN GROWTH-HORMONE PRODUCED BY RECOMBINANT ESCHERICHIA-COLI [J].

DINARELLO, CA ;

OCONNOR, JV ;

LOPRESTE, G ;

SWIFT, RL .

JOURNAL OF CLINICAL MICROBIOLOGY, 1984, 20 (03) :323-329

[3] THE DETECTION OF ENDOTOXIN BY INVITRO PRODUCTION OF ENDOGENOUS PYROGEN - COMPARISON WITH LIMULUS AMEBOCYTE LYSATE GELATION [J].

DUFF, GW ;

ATKINS, E .

JOURNAL OF IMMUNOLOGICAL METHODS, 1982, 52 (03) :323-331

[4] COMPLEMENTARY-DNA FOR A NOVEL HUMAN INTERLEUKIN (BSF-2) THAT INDUCES LYMPHOCYTES-B TO PRODUCE IMMUNOGLOBULIN [J].

HIRANO, T ;

YASUKAWA, K ;

HARADA, H ;

TAGA, T ;

WATANABE, Y ;

MATSUDA, T ;

KASHIWAMURA, S ;

NAKAJIMA, K ;

KOYAMA, K ;

IWAMATSU, A ;

TSUNASAWA, S ;

SAKIYAMA, F ;

MATSUI, H ;

TAKAHARA, Y ;

TANIGUCHI, T ;

KISHIMOTO, T .

NATURE, 1986, 324 (6092) :73-76

[5]

Pearson F.C, 1985, PYROGENS ENDOTOXINS

[6]

POOLE S, 1988, LANCET, V1, P130

[7] DEVELOPMENT AND APPLICATION OF RADIOIMMUNOASSAYS FOR INTERLEUKIN-1-ALPHA AND INTERLEUKIN-1-BETA [J].

POOLE, S ;

BRISTOW, AF ;

SELKIRK, S ;

RAFFERTY, B .

JOURNAL OF IMMUNOLOGICAL METHODS, 1989, 116 (02) :259-264

[8] THE INTERNATIONAL STANDARD FOR ENDOTOXIN - EVALUATION IN AN INTERNATIONAL COLLABORATIVE STUDY [J].

POOLE, S ;

MUSSETT, MV .

JOURNAL OF BIOLOGICAL STANDARDIZATION, 1989, 17 (02) :161-171

[9]

POOLE S, 1989, NOV P EUR WORKSH DET, P17

[10] ESTABLISHMENT AND CHARACTERIZATION OF A HUMAN ACUTE MONOCYTIC LEUKEMIA-CELL LINE (THP-1) [J].

TSUCHIYA, S ;

YAMABE, M ;

YAMAGUCHI, Y ;

KOBAYASHI, Y ;

KONNO, T ;

TADA, K .

INTERNATIONAL JOURNAL OF CANCER, 1980, 26 (02) :171-176

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