Cadherins in cancer: implications for invasion and metastasis

被引：866

作者：

Takeichi, Masatoshi ^{[1
]}

机构：

[1] Kyoto Univ, Fac Sci, Dept Biophys, Sakyo Ku, Kyoto 60601, Japan

来源：

CURRENT OPINION IN CELL BIOLOGY | 1993年 / 5卷 / 05期

关键词：

D O I：

10.1016/0955-0674(93)90029-P

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

In order to understand the mechanisms of metastasis, one must first determine how cancer cells detach from primary tumors. It is known that cadherins are major cell-cell adhesion molecules in tumors as well as in normal tissues. The perturbation of cadherin function causes temporal or permanent disaggregation of tumor cells and may thus promote the invasion and metastasis of such cells.

引用

页码：806 / 811

页数：6

共 48 条

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