THE MYOD GENE FAMILY - NODAL POINT DURING SPECIFICATION OF THE MUSCLE-CELL LINEAGE

被引：1508

作者：

WEINTRAUB, H

DAVIS, R

TAPSCOTT, S

THAYER, M

KRAUSE, M

BENEZRA, R

BLACKWELL, TK

TURNER, D

RUPP, R

HOLLENBERG, S

ZHUANG, Y

LASSAR, A

机构：

来源：

SCIENCE | 1991年 / 251卷 / 4995期

关键词：

D O I：

10.1126/science.1846704

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

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页码：761 / 766

页数：6

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