CHINESE-HAMSTER OVARIAN-CELLS TRANSFECTED WITH THE MURINE INTERLEUKIN-6 GENE CAUSE HYPERCALCEMIA AS WELL AS CACHEXIA, LEUKOCYTOSIS AND THROMBOCYTOSIS IN TUMOR-BEARING NUDE-MICE

被引：190

作者：

BLACK, K ^{[1
]}

GARRETT, IR ^{[1
]}

MUNDY, GR ^{[1
]}

机构：

[1] UNIV TEXAS,HLTH SCI CTR,SAN ANTONIO,TX 78284

来源：

ENDOCRINOLOGY | 1991年 / 128卷 / 05期

关键词：

D O I：

10.1210/endo-128-5-2657

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The effects of interleukin-6 (IL-6) in vivo were assessed by inoculating Chinese hamster ovarian (CHO) cells which were transfected with the murine IL-6 gene in nude mice. Nude mice bearing CHO cells expressing IL-6 developed hypercalcemia. Tumor-bearing mice also showed increases in white cell count, platelet count, and decreases in body weight. In nude mice carrying CHO tumors which had not been transfected with the IL-6 gene, there were no changes in these parameters. These results suggest that increased circulating concentrations of IL-6 in patients with malignant disease may contribute to a number of paraneoplastic syndromes including hypercalcemia, cachexia, leukocytosis and thrombocytosis.

引用

页码：2657 / 2659

页数：3

共 21 条

[1] PRODUCTION OF HYBRIDOMA GROWTH-FACTOR BY HUMAN-MONOCYTES [J].