RENIN INHIBITORS - DIPEPTIDE ANALOGS OF ANGIOTENSINOGEN INCORPORATING TRANSITION-STATE, NONPEPTIDIC REPLACEMENTS AT THE SCISSILE BOND

被引：48

作者：

BOLIS, G ^{[1
]}

FUNG, AKL ^{[1
]}

GREER, J ^{[1
]}

KLEINERT, HD ^{[1
]}

MARCOTTE, PA ^{[1
]}

PERUN, TJ ^{[1
]}

PLATTNER, JJ ^{[1
]}

STEIN, HH ^{[1
]}

机构：

[1] ABBOTT LABS, DIV CARDIOVASC RES, ABBOTT PK, IL 60064 USA

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1987年 / 30卷 / 10期

关键词：

D O I：

10.1021/jm00393a008

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：1729 / 1737

页数：9

共 34 条

[1]

BANGHAM DR, 1975, CLIN SCI MOL MED, V48, pS135

[2] STATINE-CONTAINING RENIN INHIBITOR - DISSOCIATION OF BLOOD-PRESSURE LOWERING AND RENIN INHIBITION IN SODIUM-DEFICIENT DOGS [J].

BLAINE, EH ;

SCHORN, TW ;

BOGER, J .

HYPERTENSION, 1984, 6 (02) :I111-I118

[3] RENIN INHIBITORS - SYNTHESES OF SUBNANOMOLAR, COMPETITIVE, TRANSITION-STATE ANALOG INHIBITORS CONTAINING A NOVEL ANALOG OF STATINE [J].

BOGER, J ;

PAYNE, LS ;

PERLOW, DS ;

LOHR, NS ;

POE, M ;

BLAINE, EH ;

ULM, EH ;

SCHORN, TW ;

LAMONT, BI ;

LIN, TY ;

KAWAI, M ;

RICH, DH ;

VEBER, DF .

JOURNAL OF MEDICINAL CHEMISTRY, 1985, 28 (12) :1779-1790

[4] ENKEPHALIN SYNTHESIS OF 2 PENTAPEPTIDES ISOLATED FROM PORCINE BRAIN WITH RECEPTOR-MEDIATED OPIATE AGONIST ACTIVITY [J].

BOWER, JD ;

GUEST, KP ;

MORGAN, BA .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1976, (23) :2488-2492

[5] SELECTIVE REDUCTIONS .21. 9-BORABICYCLO[3.3.1]NONANE IN TETRAHYDROFURAN AS A NEW SELECTIVE REDUCING AGENT IN ORGANIC-SYNTHESIS - REACTION WITH SELECTED ORGANIC-COMPOUNDS CONTAINING REPRESENTATIVE FUNCTIONAL-GROUPS [J].

BROWN, HC ;

KRISHNAMURTHY, S ;

YOON, NM .

JOURNAL OF ORGANIC CHEMISTRY, 1976, 41 (10) :1778-1791

[6] SYNTHESIS OF OXAZOLIDIN-2-ONES USING CARBONATE ION ON A POLYMERIC SUPPORT [J].

CARDILLO, G ;

ORENA, M ;

SANDRI, S ;

TOMASINI, C .

TETRAHEDRON, 1985, 41 (01) :163-167

[7] PARTIALLY MODIFIED RETRO-INVERSO PEPTIDES - COMPARATIVE CURTIUS REARRANGEMENTS TO PREPARE 1,1-DIAMINOALKANE DERIVATIVES [J].

CHOREV, M ;

GOODMAN, M .

INTERNATIONAL JOURNAL OF PEPTIDE AND PROTEIN RESEARCH, 1983, 21 (03) :258-268

[8] THE DIRECT CONVERSION OF STEROIDAL DELTA-5-3-BETA-ALCOHOLS TO DELTA-5-KETONES AND DELTA-4-3-KETONES [J].

DJERASSI, C ;

ENGLE, RR ;

BOWERS, A .

JOURNAL OF ORGANIC CHEMISTRY, 1956, 21 (12) :1547-1548

[9] PURIFICATION OF HUMAN RENIN SUBSTRATE [J].

DORER, FE ;

LENTZ, KE ;

KAHN, JR ;

LEVINE, M ;

SKEGGS, LT .

ANALYTICAL BIOCHEMISTRY, 1978, 87 (01) :11-18

[10] SIGNIFICANCE OF THE VASCULAR RENIN-ANGIOTENSIN PATHWAY [J].

DZAU, VJ .

HYPERTENSION, 1986, 8 (07) :553-559

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