学术探索
学术期刊
新闻热点
数据分析
智能评审

CYTOKINE RECEPTOR SIGNALING

被引：1106
作者：
IHLE, JN
机构：
[1] Department of Biochemistry, St Jude Children’s Research Hospital, Memphis, TN, 38101-0318, 332 North Lauderdale
来源：
NATURE | 1995年 / 377卷 / 6550期
关键词：
D O I：
10.1038/377591a0
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex. Among these are the signal transducers and activators of transcription (STATs), a family of transcription factors that contribute to the diversity of cytokine responses.
引用
收藏
页码：591 / 594
页数：4
相关论文
共 93 条
[1]   MOLECULAR-CLONING OF APRF, A NOVEL IFN-STIMULATED GENE FACTOR-3 P91-RELATED TRANSCRIPTION FACTOR INVOLVED IN THE GP130-MEDIATED SIGNALING PATHWAY [J].
AKIRA, S ;
NISHIO, Y ;
INOUE, M ;
WANG, XJ ;
WEI, S ;
MATSUSAKA, T ;
YOSHIDA, K ;
SUDO, T ;
NARUTO, M ;
KISHIMOTO, T .
CELL, 1994, 77 (01) :63-71
[2]   INTERLEUKIN-12 (IL-12) INDUCES TYROSINE PHOSPHORYLATION OF JAK2 AND TYK2 - DIFFERENTIAL USE OF JANUS FAMILY TYROSINE KINASES BY IL-2 AND IL-12 [J].
BACON, CM ;
MCVICAR, DW ;
ORTALDO, JR ;
REES, RC ;
O'SHEA, JJ ;
JOHNSTON, JA .
JOURNAL OF EXPERIMENTAL MEDICINE, 1995, 181 (01) :399-404
[3]   STRUCTURAL DESIGN AND MOLECULAR EVOLUTION OF A CYTOKINE RECEPTOR SUPERFAMILY [J].
BAZAN, JF .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (18) :6934-6938
[4]  
BHAT GJ, 1994, J BIOL CHEM, V269, P31443
[5]   STRIPE-SPECIFIC REGULATION OF PAIR-RULE GENES BY HOPSCOTCH, A PUTATIVE JAK FAMILY TYROSINE KINASE IN DROSOPHILA [J].
BINARI, R ;
PERRIMON, N .
GENES & DEVELOPMENT, 1994, 8 (03) :300-312
[6]   MECHANISM AND REGULATION OF IMMUNOGLOBULIN ISOTYPE SWITCHING [J].
COFFMAN, RL ;
LEBMAN, DA ;
ROTHMAN, P .
ADVANCES IN IMMUNOLOGY, VOL 54, 1993, 54 :229-270
[7]  
COLAMONICI O, IN PRESS MOL CELL BI
[8]  
CYSTER JG, 1995, IMMUNITY, V2, P1
[9]   JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].
DARNELL, JE ;
KERR, IM ;
STARK, GR .
SCIENCE, 1994, 264 (5164) :1415-1421
[10]  
FINBLOOM DS, 1995, J IMMUNOL, V155, P1079
12345678910