TREATMENT OF ACUTE MOUNTAIN-SICKNESS BY SIMULATED DESCENT - A RANDOMIZED CONTROLLED TRIAL

被引:45
作者
BARTSCH, P
MERKI, B
HOFSTETTER, D
MAGGIORINI, M
KAYSER, B
OELZ, O
机构
[1] UNIV HOSP ZURICH,DEPT MED,CH-8091 ZURICH,SWITZERLAND
[2] UNIV GENEVA,DEPT PHYSIOL,CH-1211 GENEVA,SWITZERLAND
[3] UNIV HEIDELBERG,MED CLIN,DEPT SPORTS MED,W-6900 HEIDELBERG,GERMANY
关键词
D O I
10.1136/bmj.306.6885.1098
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective-To evaluate the therapeutic efficacy of a portable hyperbaric chamber for treatment of acute mountain sickness. Design-Controlled randomised trial over two mountaineering seasons. Setting-High altitude research laboratory at 4559 m above sea level. Subjects-64 climbers with acute mountain sickness randomly allocated to different treatments. Interventions-One hour of treatment in the hyperbaric chamber at a pressure of 193 mbar or 20 mbar as control or bed rest. Main outcome measures-Symptoms of acute mountain sickness before, immediately after, and 12 hours after treatment. Permitted intake of analgesic and antiemetic drugs in the follow up period. Results-Treatment with 193 mbar caused greater relief of symptoms than did control treatment or bed rest. During the 12 hour follow up period intake of analgesics was similar (58-80% of subjects in each group). Symptom scores had improved in all subjects after 12 hours with no significant differences between groups. Conclusions-One hour of treatment with 193 mbar in a portable hyperbaric chamber, corresponding to a descent of 2250 m, leads to a short term improvement in symptoms of acute mountain sickness but has no beneficial long term effects attributable to pressurisation.
引用
收藏
页码:1098 / 1101
页数:4
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