THE YEAST DOA4 GENE ENCODES A DEUBIQUITINATING ENZYME RELATED TO A PRODUCT OF THE HUMAN TRE-2 ONCOGENE

被引：343

作者：

PAPA, FR

HOCHSTRASSER, M

机构：

[1] Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, IL 60637

来源：

NATURE | 1993年 / 366卷 / 6453期

关键词：

D O I：

10.1038/366313a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Modification of specific intracellular proteins by ubiquitin targets them for degradation. We describe a yeast enzyme, Doa4, that is integral to the degradation of ubiquitinated proteins and is required in diverse physiological processes. Doa4 appears to function late in the proteolytic pathway by cleaving ubiquitin from substrate remnants still bound to protease. The human tre-2 oncogene encodes a deubiquitinating enzyme similar to Doa4, indicating a role for the ubiquitin system in mammalian growth control.

引用

页码：313 / 319

页数：7

共 45 条

[1] BASIC LOCAL ALIGNMENT SEARCH TOOL [J].