EFFECT OF ANTIBIOTICS ON NONGROWING PLANKTONIC CELLS AND BIOFILMS OF ESCHERICHIA-COLI

被引：83

作者：

ASHBY, MJ ^{[1
]}

NEALE, JE ^{[1
]}

KNOTT, SJ ^{[1
]}

CRITCHLEY, IA ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,CHEMOTHERAPEUT RES CTR,BROCKHAM PK,BETCHWORTH RH3 7AJ,SURREY,ENGLAND

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1994年 / 33卷 / 03期

关键词：

D O I：

10.1093/jac/33.3.443

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Several classes of antibiotics were assessed for activity against non-growing Escherichia coli and cells grown as a biofilm. Antibiotics which had activity against non-growing cells also showed some activity against biofilms. Cephamycins were more active than other cephalosponns, but the most effective antibiotics were imipenem and ciprofloxacin, which were also active against steady state biofilms However, none of the antibiotics studied was capable of completely eradicating a biofilm. These results suggest that growth rate plays a role in mediating resistance of biofilms to antibiotics. © 1994 The British Society for Antimicrobial Chemotherapy.

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页码：443 / 452

页数：10

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