NEURON ATROPHY DURING AGING - PROGRAMMED OR SPORADIC

被引：143

作者：

FINCH, CE ^{[1
]}

机构：

[1] UNIV SO CALIF,DEPT BIOL SCI,LOS ANGELES,CA 90089

来源：

TRENDS IN NEUROSCIENCES | 1993年 / 16卷 / 03期

关键词：

D O I：

10.1016/0166-2236(93)90134-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Atrophy of neurons is a common change during aging in laboratory rodents and humans. However, cholinergic neurons of the same type have been found to atrophy, hypertrophy or not change at all, according to various reports on different species and genotypes. Possible factors responsible for these diverse outcomes include species- and genotype-specific aging changes and age-related diseases. An open question is whether slowly evolving changes in neuronal size share any mechanisms with the rapid programmed death of neurons that occurs during development. Progress in the study of neuronal atrophy with aging may be furthered by using fewer rodent genotypes.

引用

页码：104 / 110

页数：7

共 51 条

[1] AGING IS ASSOCIATED WITH A DIFFUSE IMPAIRMENT OF FOREBRAIN CHOLINERGIC NEURONS [J].