INTERLEUKIN-1 MEDIATES BEHAVIORAL BUT NOT METABOLIC EFFECTS OF TUMOR-NECROSIS-FACTOR-ALPHA IN MICE

被引：72

作者：

BLUTHE, RM ^{[1
]}

DANTZER, R ^{[1
]}

KELLEY, KW ^{[1
]}

机构：

[1] UNIV ILLINOIS,DEPT ANIM SCI,IMMUNOPHYSIOL LAB,PLANT & ANIM BIOTECHNOL LAB,URBANA,IL 61801

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 209卷 / 03期

关键词：

TUMOR NECROSIS FACTOR; INTERLEUKIN-1; INTERLEUKIN-1 RECEPTOR ANTAGONISTS; SOCIAL BEHAVIOR; BODY WEIGHT; (MOUSE);

D O I：

10.1016/0014-2999(91)90184-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Recombinant human tumor necrosis factor-alpha (TNF-alpha) decreases social exploration and induces weight loss in mice in a dose- and time-dependent manner (2.5-40-mu-g/mouse). To assess the role of interleukin-I (IL-1) in these effects, mice pretreated with IL-1 receptor antagonist (IL-1ra, 500-mu-g/mouse, i.p.) were injected with 25-mu-g TNF-alpha. Pretreatment with IL-1ra antagonized the depressive effects of TNF-alpha on behaviour but only partially attenuated the weight loss induced by this cytokine. These results suggest that TNF-alpha-induced sickness behaviour is mediated mainly by endogenously released IL-1 whereas metabolic changes are dependent on the release of other additional cytokines.

引用

页码：281 / 283

页数：3

共 9 条

[1] BIOLOGICAL PROPERTIES OF RECOMBINANT HUMAN MONOCYTE-DERIVED INTERLEUKIN-1 RECEPTOR ANTAGONIST [J].

AREND, WP ;

WELGUS, HG ;

THOMPSON, RC ;

EISENBERG, SP .

JOURNAL OF CLINICAL INVESTIGATION, 1990, 85 (05) :1694-1697

[2] THE PROINFLAMMATORY CYTOKINES INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR AND TREATMENT OF THE SEPTIC SHOCK SYNDROME [J].

DINARELLO, CA .

JOURNAL OF INFECTIOUS DISEASES, 1991, 163 (06) :1177-1184

[3]

DRIPPS DJ, IN PRESS INTERLEUKIN

[4] ANTIBODIES TO CACHECTIN TUMOR NECROSIS FACTOR REDUCE INTERLEUKIN-1-BETA AND INTERLEUKIN-6 APPEARANCE DURING LETHAL BACTEREMIA [J].

FONG, YM ;

TRACEY, KJ ;

MOLDAWER, LL ;

HESSE, DG ;

MANOGUE, KB ;

KENNEY, JS ;

LEE, AT ;

KUO, GC ;

ALLISON, AC ;

LOWRY, SF ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1627-1633

[5] INTERLEUKIN-1 RECEPTOR ANTAGONIST ACTIVITY OF A HUMAN INTERLEUKIN-1 INHIBITOR [J].

HANNUM, CH ;

WILCOX, CJ ;

AREND, WP ;

JOSLIN, FG ;

DRIPPS, DJ ;

HEIMDAL, PL ;

ARMES, LG ;

SOMMER, A ;

EISENBERG, SP ;

THOMPSON, RC .

NATURE, 1990, 343 (6256) :336-340

[6] FEVER - ROLE OF PYROGENS AND CRYOGENS [J].

KLUGER, MJ .

PHYSIOLOGICAL REVIEWS, 1991, 71 (01) :93-127

[7] INTERLEUKIN-1 RECEPTOR ANTAGONIST REDUCES MORTALITY FROM ENDOTOXIN-SHOCK [J].

OHLSSON, K ;

BJORK, P ;

BERGENFELDT, M ;

HAGEMAN, R ;

THOMPSON, RC .

NATURE, 1990, 348 (6301) :550-552

[8] INTERLEUKIN-1-RECEPTOR ANTAGONIST BLOCKS INTERLEUKIN-1-INDUCED SLEEP AND FEVER [J].

OPP, MR ;

KRUEGER, JM .

AMERICAN JOURNAL OF PHYSIOLOGY, 1991, 260 (02) :R453-R457

[9]

1991, LAB INVEST, V64, P724

← 1 →