CHEMICAL EVIDENCE FOR PRODUCTION OF HYDROXYL RADICALS DURING MICROSOMAL ELECTRON-TRANSFER

被引：81

作者：

COHEN, G

CEDERBAUM, AI

机构：

[1] CUNY MT SINAI SCH MED,DEPT BIOCHEM,NEW YORK,NY 10029

[2] CUNY MT SINAI SCH MED,ALCOHOL RES CTR,NEW YORK,NY 10029

来源：

SCIENCE | 1979年 / 204卷 / 4388期

关键词：

D O I：

10.1126/science.432627

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Rat liver microsomes generate methane from dimethyl sulfoxide and ethylene from either methional or 2-keto-4-thiomethylbutyric acid during electron transfer initiated by reduced nicotinamide-adenine dinucleotide phosphate (NADPH). Hydrocarbon gas production is suppressed by hydroxyl radical scavenging agents. Azide, an inhibitor of catalase, augments the production of hydrocarbon gases. These observations constitute chemical evidence for the generation of hydroxyl radicals by microsomes. Copyright © 1979 AAAS.

引用

页码：66 / 68

页数：3

共 43 条

[1] A COMPILATION OF SPECIFIC BIMOLECULAR RATE CONSTANTS FOR REACTIONS OF HYDRATED ELECTRONS HYDROGEN ATOMS AND HYDROXYL RADICALS WITH INORGANIC AND ORGANIC COMPOUNDS IN AQUEOUS SOLUTION [J].