INTRATHECAL CAPSAICIN DEPLETES SUBSTANCE-P IN THE RAT SPINAL-CORD AND PRODUCES PROLONGED THERMAL ANALGESIA

被引：292

作者：

YAKSH, TL

FARB, DH

LEEMAN, SE

JESSELL, TM

机构：

[1] HARVARD UNIV, SCH MED, DEPT PHYSIOL, BOSTON, MA 02115 USA

[2] HARVARD UNIV, SCH MED, DEPT PHARMACOL, BOSTON, MA 02115 USA

来源：

SCIENCE | 1979年 / 206卷 / 4417期

关键词：

D O I：

10.1126/science.228392

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

A single intrathecal injection of capsaicin depletes substance P from primary sensory neurons and causes a prolonged increase in the thermal and chemical pain thresholds of the rat but no apparent change in responses to noxious mechanical stimuli. Copyright © 1979 AAAS.

引用

收藏

页码：481 / 483

页数：3

相关论文

共 25 条

[1] ORIGIN, DISTRIBUTION AND SYNAPTIC RELATIONSHIPS OF SUBSTANCE-P AXONS IN RAT SPINAL-CORD [J].

BARBER, RP ;

VAUGHN, JE ;

SLEMMON, JR ;

SALVATERRA, PM ;

ROBERTS, E ;

LEEMAN, SE .

JOURNAL OF COMPARATIVE NEUROLOGY, 1979, 184 (02) :331-351

[2] EFFECTS OF CENTRAL LESIONS ON DISORDERS PRODUCED BY MULTIPLE DORSAL RHIZOTOMY IN RATS [J].

BASBAUM, AI .

EXPERIMENTAL NEUROLOGY, 1974, 42 (03) :490-501

[3] ULTRASTRUCTURAL IDENTIFICATION OF SUBSTANCE P-CELLS AND THEIR PROCESSES IN RAT SENSORY GANGLIA AND THEIR TERMINALS IN SPINAL-CORD BY IMMUNOCYTOCHEMISTRY - (GRANULES-STORAGE-RELEASE-EXTRACELLULAR-SYNAPTIC) [J].

CHANPALAY, V ;

PALAY, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (09) :4050-4054

[4] SEROTONIN AND SUBSTANCE-P COEXIST IN NEURONS OF RATS CENTRAL NERVOUS-SYSTEM [J].

CHANPALAY, V ;

JONSSON, G ;

PALAY, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1978, 75 (03) :1582-1586

[5] SUBSTANCE-P - LOCALIZATION IN SYNAPTIC VESICLES IN RAT CENTRAL NERVOUS-SYSTEM [J].

CUELLO, AC ;

JESSELL, TM ;

KANAZAWA, I ;

IVERSEN, LL .

JOURNAL OF NEUROCHEMISTRY, 1977, 29 (04) :747-+

[6]

GASPAROVIC I, 1964, MED EXP, V10, P303

[7] EFFECTS OF SUBSTANCE-P ON FUNCTIONALLY IDENTIFIED UNITS IN CAT SPINAL-CORD [J].

HENRY, JL .

BRAIN RESEARCH, 1976, 114 (03) :439-451

[8] IMMUNOHISTOCHEMICAL EVIDENCE OF SUBSTANCE P-LIKE IMMUNOREACTIVITY IN SOME 5-HYDROXYTRYPTAMINE-CONTAINING NEURONS IN RAT CENTRAL NERVOUS-SYSTEM [J].

HOKFELT, T ;

LJUNGDAHL, A ;

STEINBUSCH, H ;

VERHOFSTAD, A ;

NILSSON, G ;

BRODIN, E ;

PERNOW, B ;

GOLDSTEIN, M .

NEUROSCIENCE, 1978, 3 (06) :517-+

[9] EXPERIMENTAL IMMUNOHISTOCHEMICAL STUDIES ON LOCALIZATION AND DISTRIBUTION OF SUBSTANCE-P IN CAT PRIMARY SENSORY NEURONS [J].

HOKFELT, T ;

KELLERTH, JO ;

NILSSON, G ;

PERNOW, B .

BRAIN RESEARCH, 1975, 100 (02) :235-252

[10] IMMUNOHISTOCHEMICAL ANALYSIS OF PEPTIDE PATHWAYS POSSIBLY RELATED TO PAIN AND ANALGESIA - ENKEPHALIN AND SUBSTANCE-P [J].

HOKFELT, T ;

LJUNGDAHL, A ;

TERENIUS, L ;

ELDE, R ;

NILSSON, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1977, 74 (07) :3081-3085