VASOCONSTRICTOR AND DILATOR RESPONSES TO NEUROKININ-A IN ISOLATED GUINEA-PIG HEART

被引：23

作者：

HOOVER, DB ^{[1
]}

HOSSLER, FE ^{[1
]}

机构：

[1] E TENNESSEE STATE UNIV,JAMES H QUILLEN COLL MED,DEPT ANAT,JOHNSON CITY,TN 37614

来源：

PEPTIDES | 1993年 / 14卷 / 01期

关键词：

NEUROKININS; VASOCONSTRICTION; VASODILATION; RESISTANCE VESSELS; HEART; GUINEA PIG;

D O I：

10.1016/0196-9781(93)90007-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Effects of neurokinin A (NKA) and substance P (SP) on coronary resistance vessels were studied in isolated guinea pig hearts perfused with isotonic buffer containing 20 mM KCl. Injections of NKA and SP caused dose-dependent reductions in perfusion pressure with ED50 values of 14.0 and 0.326 pmol, respectively. Blockade of nitric oxide synthesis or removal of the endothelium inhibited vasodilator responses to neurokinins. Infusions of NKA or SP caused tachyphylaxis and cross-desensitization to the other neurokinin but not to acetylcholine. Injections of 2.5 nmol NKA increased perfusion pressure by 31 +/- 8% when given after tachyphylaxis developed to infused SP (2.5 nmol/100 mul/min). It was concluded that 1) neurokinins cause an endothelium-dependent relaxation of coronary resistance vessels by stimulating NK-1 receptors on endothelial cells, and 2) desensitization of the receptor mediating vasodilation unmasks a vasoconstrictor response to NKA.

引用

页码：29 / 36

页数：8

共 38 条

[1] EFFECT OF SUBSTANCE-P ON THE MEMBRANE-POTENTIAL OF CORONARY ARTERIAL ENDOTHELIAL-CELLS INSITU [J].

BENY, JL .

AGENTS AND ACTIONS, 1990, 31 (3-4) :317-320

[2]

BENY JL, 1988, BLOOD VESSELS, V25, P308

[3] THE INFLUENCE OF ATHEROSCLEROSIS ON THE MECHANICAL RESPONSES OF HUMAN ISOLATED CORONARY-ARTERIES TO SUBSTANCE-P, ISOPRENALINE AND NORADRENALINE [J].

BERKENBOOM, G ;

DEPIERREUX, M ;

FONTAINE, J .

BRITISH JOURNAL OF PHARMACOLOGY, 1987, 92 (01) :113-120

[4] ANGIOGRAPHIC ASSESSMENT OF HUMAN CORONARY-ARTERY ENDOTHELIAL FUNCTION BY MEASUREMENT OF ENDOTHELIUM-DEPENDENT VASODILATION [J].

BOSSALLER, C ;

HEHLERTFRIEDRICH, C ;

JOST, S ;

RAFFLENBEUL, W ;

LICHTLEN, P .

EUROPEAN HEART JOURNAL, 1989, 10 :44-48

[5] SUBSTANCE-P DISTRIBUTION AND EFFECTS IN THE CANINE EPICARDIAL CORONARY-ARTERIES [J].

BRUM, JM ;

GO, VLW ;

SUFAN, Q ;

LANE, G ;

REILLY, W ;

BOVE, AA .

REGULATORY PEPTIDES, 1986, 14 (01) :41-55

[6]

BRUNET PC, 1989, BLOOD VESSELS, V26, P228

[7]

CHEN Y, 1991, J CLIN PHARMACOL, V31, P288

[8] THE ROLE OF NITRIC-OXIDE IN MEDIATING ENDOTHELIUM DEPENDENT RELAXATIONS IN THE HUMAN EPICARDIAL CORONARY-ARTERY [J].

CHESTER, AH ;

ONEIL, GS ;

TADJKARIMI, S ;

PALMER, RMJ ;

MONCADA, S ;

YACOUB, MH .

INTERNATIONAL JOURNAL OF CARDIOLOGY, 1990, 29 (03) :305-309

[9] SMOOTH-MUSCLE PHARMACOLOGY OF SUBSTANCE-P [J].

COUTURE, R ;

REGOLI, D .

PHARMACOLOGY, 1982, 24 (01) :1-25

[10] SUBSTANCE-P DILATES EPICARDIAL CORONARY-ARTERIES AND INCREASES CORONARY BLOOD-FLOW IN HUMANS [J].

CROSSMAN, DC ;

LARKIN, SW ;

FULLER, RW ;

DAVIES, GJ ;

MASERI, A .

CIRCULATION, 1989, 80 (03) :475-484

← 1 2 3 4 →